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KMID : 0606920110190030288
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Biomolecules & Therapeutics
2011 Volume.19 No. 3 p.288 ~ p.295
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Neuroprotective Effect of L-Theanine on Aβ-Induced Neurotoxicity through Anti-Oxidative Mechanisms in SK-N-SH and SK-N-MC Cells
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Jo Mi-Ran
Park Mi-Hee
Choi Dong-Young
Yuk Dong-Yeun
Lee Yuk-Mo
Lee Jin-Moo
Jeong Jae-Hwang
Oh Ki-Wan
Lee Moon-Soon
Han Sang-Bae
Hong Jin-Tae
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Abstract
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Amyloid beta (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer' disease (AD). In this study, we investigated the inhibitory effect of L-theanine, a component of green tea (Camellia sinensis) on Aβ1-42-induced neurotoxicity and oxidative damages of macromolecules. L-theanine inhibited Aβ1-42-induced generation of reactive oxygen species, and activation of extracellular signal-regulated kinase and p38 mitogenic activated protein kinase as well as the activity of nuclear factor kappa- B. L-theanine also signifi cantly reduced oxidative protein and lipid damage, and elevated glutathione level. Consistent with the reduced neurotoxic signals, L-theanine (10-50 ?g/ml) concomitantly attenuated Aβ1-42 (5 ?M)-induced neurotoxicity in SK-N-MC and SK-N-SH human neuroblastoma cells. These data indicate that L-theanine on Aβ-induced neurotoxicity prevented oxidative damages of neuronal cells, and may be useful in the prevention and treatment of neurodegenerative disease like AD.
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KEYWORD
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L-theanine, Amyloid beta, Oxidative stress, Neuronal damages
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